What is basal cell adenoma?
Basal cell adenoma (BCA) is a rare benign epithelial tumor of the salivary gland, displaying monomorphic basaloid cells without a myxochondroid component, representing 1–3% of all salivary gland neoplasms seen predominantly in women over 50 years of age. It is uncommon in young adults.
What is salivary glands?
Salivary glands make saliva, which aids in digestion, keeps your mouth moist and supports healthy teeth. You have three pairs of major salivary glands under and behind your jaw — parotid, sublingual and submandibular.
What are the minor salivary glands?
Minor salivary glands are a subset of the salivary glands. They are small and unnamed salivary glandular tissue scattered throughout the oral cavity and oropharynx as well as more widely in the mucosa of the aerodigestive tract.
What causes basal cell adenoma?
Some patients can have a membranous basal cell adenoma of the salivary gland. It is caused by germline mutations in the CYLD gene (16q12-q13). Which of the following markers is most useful to differentiate tubular / trabecular predominant basal cell adenoma from pleomorphic adenoma?
How serious is pleomorphic adenoma?
Although it is classified as benign, a pleomorphic adenoma can undergo a malignant transformation, with a tendency to recur. In 5% of cases, in fact, if it is not surgically removed, a pleomorphic adenoma can degenerate into a carcinoma (taking the name of Carcinoma ex Pleomorphic Adenoma).
Can pleomorphic adenoma be cured?
While surgical resection usually cures the individual, there is a risk of recurrence of parotid tumors if the adenoma is not completely removed. If the tumor is poorly encapsulated, the entire parotid gland may be removed in a procedure known as a total parotidectomy.
What is Canalicular adenoma?
Canalicular adenoma is a benign, epithelial salivary gland neoplasm arranged in interconnecting cords of columnar cells. This is a very rare benign neoplasm, that makes up about 1% of all salivary gland tumors, or about 4% of all benign salivary gland tumors.
Is there an immunohistochemical (IHC) analysis of Canalicular adenoma (Canad)?
There is a lack of a comprehensive immunohistochemical (IHC) analysis of canalicular adenoma (CanAd), especially when combined with a description of the unique histologic features. Given the usual small biopsies, IHC may be useful in distinguishing CanAd from other tumors in the differential diagnosis. Retrospective.
What is the difference between basal cell adenoma and adenoid cystic carcinoma?
While the main differential diagnosis to consider is basal cell adenoma (BCA), similar histological patterns and multifocality have been observed in adenoid cystic carcinoma (ACC) and polymorphous low-grade adenocarcinoma (PLGA), both locally-aggressive malignancies which require radically different treatment to CA.
What is the retired terminology for salivary adenoma?
Retired terminology: canalicular tumor; canalicular mixed tumor; monomorphic adenoma, canalicular type; cystic adenoma; adenomatosis of accessory salivary glands Extremely rare in major salivary glands (parotid); consider HMGA2-WIF1 fusion pleomorphic adenoma in differential diagnosis