What are alkyl sulfonates used for?
Long-chain alkyl sulfonates are commonly used for the separation of water-soluble basic analytes as shown in Figure 16 in the analysis of water-soluble vitamins (WSV). Hexanesulfonate binds with basic analytes such as pyridoxine and thiamine to form ion-pairs.
Do alkylating agents cause cancer?
Consequently, although alkylating agents can induce cancer, they are also used to treat cancer.
How do alkylating agents affect cancer cells?
Alkylating agents keep the cell from reproducing (making copies of itself) by damaging its DNA. These drugs work in all phases of the cell cycle and are used to treat many different cancers, including cancers of the lung, breast, and ovary as well as leukemia, lymphoma, Hodgkin disease, multiple myeloma, and sarcoma.
What is the difference between LAS and Labsa?
LABSA became the first surfactant that was introduced to improve the environment problems the industry posed. The replacement was due to the branched Alkylbenzene Sulfonate being resistant to biodegradation by bacteria. In comparison, LAS has a very high level of biodegradation (97 – 99%).
Is alkyl benzene sulfonate harmful?
Studies have shown that linear alkylbenzene sulfonate (LAS), a type of omnipresent pollutant, can cause toxic damage to aquatic plants.
Which chemotherapy drug is an alkylating agent?
Examples of alkylating agents include chlorambucil, cyclophosphamide, thiotepa, and busulfan.
What is the enzyme that kills cancer cells?
Cancer cells adapt by spewing enzymes that neutralize the acid. The researchers discovered that inhibiting one of those enzymes, Carbonic Anhydrase IX (CAIX), while simultaneously promoting a form of cancer-cell death, slows tumor growth. They published their findings in the journal Science Advances.
Is Labsa hazardous?
The product is harmful if ingested. Doc. # LABSA-MSDS-08 Effective Date 01.05.
Is sulfonate toxic?
What is the use of alkyl sulfonate in chemical analysis?
Long-chain alkyl sulfonates are commonly used for the separation of water-soluble basic analytes as shown in Figure 16 in the analysis of water-soluble vitamins (WSV). Hexanesulfonate binds with basic analytes such as pyridoxine and thiamine to form ion-pairs.
Is linear alkylbenzene sulfonate a cytotoxic surfactant?
Abstract Linear alkylbenzene sulfonate (LAS) is a cytotoxic synthetic anionic surfactant widely present in the environment due to its large-scale production and intensive use in the detergency field.
Why are alkylating agents used to treat cancer?
Michael Colvin, MD. The alkylating agents were the first nonhormonal drugs to be used effectively in the treatment of cancer, and the story behind the recognition of the antitumor effects of these compounds is a remarkable one. During World War I, toxic gases were used as military weapons.
What is an example of an SN1 alkylating agent?
The nitrogen mustards and nitrosoureas are examples of SN1 agents, whereas busulfan is an SN2 agent. Figure 51-2 SN1 and SN2 reactions of alkylating agents. A large number of chemical compounds are alkylating agents under physiologic conditions, and a variety of such compounds have antitumor activity.