Is alendronate same as bisphosphonate?
Alendronate is in a class of medications called bisphosphonates. It works by preventing bone breakdown and increasing bone density (thickness).
What does farnesyl pyrophosphate synthase do?
Farnesyl pyrophosphate synthase (FPPS) is a key branch point enzyme in the mevalonate pathway, the exclusive route of isoprenoid production in animals, involved in cholesterol biosynthesis and synthesis of intermediates important for intracellular signalling and growth control [1].
What is the difference between alendronate and ibandronate?
Fosamax (alendronate) is a first-choice treatment for osteoporosis, but taking it can be a hassle. Prevents bone loss. Boniva (ibandronate) is a first-choice treatment for osteoporosis and is available as a generic, but how you have to take it can be a hassle. It’s also only approved for women, not men.
What is the difference between Fosamax and Prolia?
Fosamax (alendronate sodium) and Prolia (denosumab) are used to treat and prevent osteoporosis. Fosamax is also used to treat Paget’s disease. Fosamax and Prolia belong to different drug classes. Fosamax is a bisphosphonate and Prolia is a monoclonal antibody.
What is the difference between Fosamax and alendronate?
Alendronate is commonly known by the brand name Fosamax®. Fosamax® is a bisphosphonate and is used in the treatment of osteoporosis. Fosamax® decreases the rate bone cells are absorbed. This reduced absorption allows the body to increase bone density, which in turn reduces the risk of fracture.
What is the most potent bisphosphonate?
The most potent bisphosphonates to date, risedronate and zoledronate, contain a nitrogen atom within a heterocyclic ring. They are up to 10 000 times more potent than etidronate in some experimental systems.
What type of inhibitor is bisphosphonate?
Bisphosphonates are highly effective inhibitors of bone resorption. This class of agents includes alendronate, etidronate, pamidronate, ibandronate, risedronate, clodronate, tiludronate, and zoledronate, which are variously used as the free acid or as the sodium salts.
Is Fosamax or Boniva better?
Based on several studies, we know that Fosamax also reduces the risk of hip fractures and nonvertebral fractures. But we aren’t quite sure whether Boniva reduces the risk of hip or nonvertebral fractures. Because of this, clinical guidelines generally recommend Fosamax over Boniva.
What are base phosphate bisphosphonates?
Bisphosphonates are pyrophosphate analogs which contain a phosphate-carbon-phosphate (P-C-P) core structure that targets them to bone and renders them resistant to enzymatic degradation.
What is the difference between biphosphate and diphosphates?
Biphosphate vs Diphosphate – What’s the difference? is that biphosphate is (inorganic chemistry) any salt of phosphoric acid in which only one of the hydrogen atome has been replaced by a metal ion while diphosphate is (chemistry) any salt or ester containing two phosphate groups. Other Comparisons: What’s the difference?
Do bisphosphonates need to be taken with water?
All bisphosphonates are very poorly absorbed from the gastrointestinal tract (1%–2% of administered dose). The low bioavailability of orally administered bisphosphonates is a critical issue in their use. They must be taken fasting, or with water alone if they are to be absorbed at all.
Should bisphosphonates be used to treat osteoporosis?
The available evidence, therefore, supports the use of either alendronate or risedronate as the preferred bisphosphonate for treatment of osteoporosis, since each of these drugs has been shown in randomized controlled trials to decrease rates of both vertebral and nonvertebral fractures.