What causes Torocytes?
Torocytes are an artefact due to blood smears from animals with a low PCV. Microcytosis may also be seen in other circumstances, such as portosystemic shunts (PSS). In young dogs with appropriate symptoms this should raise suspicion of a PSS.
What causes Macroovalocytes?
In most instances, the macroovalocyte morphology is due to megaloblastic erythropoiesis (Vitamin B-12 or folate deficiency) but may be seen with dyserythropoiesis. Although macroovalocytes are characteristic in these deficiency states, they are not pathognomonic.
Why megaloblasts are formed?
nucleated red cells known as megaloblasts, develops as the result of dietary deficiency of, faulty absorption of, or increased demands for vitamin B12 or folic acid.
What does Macrocytes present mean?
Macrocytosis is a term used to describe red blood cells that are larger than normal.
What causes macrocytosis without anemia?
Macrocytosis is most commonly caused by alcoholism, Vitamin B12 deficiency and medications. Even in the absence of anemia, an increased MCV needs to be evaluated, as it may be the only clue to an underlying pathological condition.
What causes B-12 and folate deficiency?
Causes of a vitamin B12 or folate deficiency a lack of these vitamins in your diet – this is uncommon, but can happen if you have a vegan diet and do not take vitamin B12 supplements or eat foods fortified with vitamin B12 , follow a fad diet or have a generally poor diet for a long time.
What is indicated by the presence of megaloblasts in the blood?
Megaloblastic anemia (MA) encompasses a heterogeneous group of anemias characterized by the presence of large red blood cell precursors called megaloblasts in the bone marrow. This condition is due to impaired DNA synthesis, which inhibits nuclear division.
What causes poikilocytosis?
Poikilocytosis is usually caused by another medical condition, such as anemia, liver disease, alcoholism, or an inherited blood disorder. For this reason, the presence of poikilocytes and the shape of the abnormal cells are helpful in diagnosing other medical conditions.
What happens if your poikilocytes are high?
An increased number of poikilocytes can be life-threatening for the individual too. These abnormal red blood cells can interfere with blood circulation, oxygen transfer and nutrient supply. (3)
What is a poikilocyte?
The term “poikilocyte” is a generic or umbrella term to describe erythrocytes with abnormal shape. We can subclassify poikilocytes by specific shape changes, some of which have fairly unique diagnostic significance, while other forms are quite non-specific.
What are the different types of poikilocytosis?
The most common types of poikilocytosis are sickle cells, target cell, spherocytes, elliptocytes, ovalocytes, echinocytes, and acanthocytes. They are usually identified on the blood smear and play an important role in diagnosing the underlying cause and its management. Treatment and prognosis vary depending on the cause of the poikilocytosis.