What do you mean by combinatorial synthesis?
From the stand point of the synthetic chemist, Combinatorial Synthesis involves the use of processes (solid phase synthesis) and strategies (hundreds or thousands of simultaneous reactions) which allow the preparation, in a short time, of big, organized collections of organic compounds, the so called molecular …
What is combinatorial synthesis and its advantage?
(1) The creation of large libraries of molecules in a short time is the main advantage of combinatorial chemistry over traditional. (2)Compounds that cannot be synthesized using traditional methods of medicinal chemistry can be synthesized using combinatorial techniques.
Which method is used in combinatorial synthesis?
Combinatorial chemistry uses chemical synthesis methods that make it possible to prepare a large number (up to even millions) of compositions in a single process. Combinatorial chemistry also includes strategies that allow identification of useful components of the libraries for such large-scale synthesis.
What is combinatorial chemistry describe the solid phase and solution phase synthesis?
A common combinatorial technique uses organic synthesis on solid support. Linker groups are attached to resin beads in the solid phase and the reactants are passed over in solution to make the intermediates and a final detachment-from-resin reaction is run to get the desired product out of the column.
What is the role of combinatorial chemistry in drug discovery process?
Combinatorial chemistry has accelerated the development of a whole set of combinatorial tools comprising combinatorial library design, efficient synthetic methods, reagents for library synthesis (including solid supported reagents), linkers, bilayer beads, library encoding and decoding strategies, HTS methods and …
What are the applications of combinatorial chemistry?
The application of combinatorial chemistry science has revolutionized high-throughput screening paradigms, chemical lead optimization, library purification and postpurification sample handling, as well as in vitro and in vivo drug metabolism and pharmacokinetic assays.
What is combinatorial synthesis?
Combinatorial synthesis is a newly emerging paradigm of research methodology which aims to drastically increase the efficiency at which new materials are discovered and improved.
How is combinatorial chemistry used in peptide synthesis?
The combinatorial chemistry first shows its presence in synthesis of peptide libraries. The peptide plays varying role in body. By the use of combinatorial chemistry we can generate vast peptide, which may be active.
What are the methods of combinatorial chemistry?
There are two methods, which used for synthesis of compounds in combinatorial chemistry. They include: This technique was pioneered by Furka and co-workers in 1988 for the synthesis of large peptide libraries. This approach is termed divide couple and recombine synthesis by other workers.
What is combinatorial split-mix peptide synthesis?
Combinatorial split-mix (split and pool) synthesis is based on the solid-phase synthesis developed by Merrifield. If a combinatorial peptide library is synthesized using 20 amino acids (or other kinds of building blocks) the bead form solid support is divided into 20 equal portions.