What is the meaning of cathepsin?
Medical Definition of cathepsin : any of a class of proteases present in most animal tissues (as in kidney, liver, and spleen) that catalyze the hydrolysis of proteins to polypeptides Cathepsins are lysosomal proteases that cleave their substrates with relatively low specificity.—
Where is cathepsin located?
Abstract: Cathepsins are the most abundant lysosomal proteases that are mainly found in acidic endo/lysosomal compartments where they play a vital role in intracellular protein degradation, energy metabolism, and immune responses among a host of other functions.
What enzyme causes inflammation?
The most important mediators that generate an acute inflammatory reaction are derived from the digestive proteases and lipases (54, 119).
What is the role of cathepsin S in lung diseases?
Dysregulated expression and activity of cathepsin S (CTSS), a lysosomal protease and a member of the cysteine cathepsin protease family, is linked to the pathogenesis of multiple diseases, including a number of conditions affecting the lungs.
What can replace cathepsin S in macrophages?
In macrophages, cathepsin S can be replaced by cathepsin F . Secreted cathepsin S cleaves some extracellular matrix (ECM) proteins. Cathepsin S may be considered the most potent elastase known. The list of proposed cathepsin S substrates includes laminin, fibronectin elastin, osteocalcin and some collagens.
How does cathepsin S control angiogenesis and tumor growth?
Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors. J Biol Chem. 2006;281:6020–9.
What cells express cathepsin S?
Cathepsin S is expressed by antigen presenting cells including macrophages, B-lymphocytes, dendritic cells and microglia. Cathepsin S is expressed by some epithelial cells.