What is type 2 Diabitis?
Type 2 diabetes is an impairment in the way the body regulates and uses sugar (glucose) as a fuel. This long-term (chronic) condition results in too much sugar circulating in the bloodstream. Eventually, high blood sugar levels can lead to disorders of the circulatory, nervous and immune systems.
Can diabetics do autophagy?
Recent studies have confirmed that autophagy plays a pivotal role in diabetes and its complications. It has been observed that autophagy regulates the normal function of pancreatic β cells and insulin-target tissues, such as skeletal muscle, liver, and adipose tissue.
What is the difference between Type 1 and typ2 diabetes?
The main difference between the type 1 and type 2 diabetes is that type 1 diabetes is a genetic condition that often shows up early in life, and type 2 is mainly lifestyle-related and develops over time. With type 1 diabetes, your immune system is attacking and destroying the insulin-producing cells in your pancreas.
What happens when a1c is too high?
If your blood glucose stays high over time, it can damage the tiny blood vessels in the back of your eyes. This damage can begin during prediabetes. Damaged blood vessels may leak fluid and cause swelling. New, weak blood vessels may also begin to grow.
Does insulin stop autophagy?
Additionally, it is well-recognized that insulin can inhibit autophagy, through the aforementioned activation of mTORC1 leading to ULK1 phosphorylation (inhibition), and inactivation of FOXO transcription factors.
Does insulin inhibit autophagy?
Insulin inhibits autophagy through phosphorylation of ULK1 at Ser757, and this is associated with decreased protein degradation in human skeletal muscle (22). Moreover, the expression of autophagy-related proteins is repressed in patients with type 2 diabetes treated with high doses of insulin (15).
Can type 2 diabetes turn to type 1?
If you were recently diagnosed with type 2 diabetes, understand that your condition can’t eventually turn into type 1 diabetes. However, there’s a small possibility that your type 2 diabetes is actually LADA, or type 1.5 diabetes.