What are examples of Nephrotoxins?

What are examples of Nephrotoxins?

What are examples of Nephrotoxins?

Direct tubular nephrotoxins include aminoglycosides, vancomycin, amphotericin, cisplatin, calcineurin inhibitors (CNIs), and radiographic contrast media.

What are the most common nephrotoxic drugs?

The nephrotoxic effects of cyclosporine, aminoglycoside antibiotics, cisplatin, amphotericin B, beta-lactam antibiotics and indomethacin are reviewed. These drugs were chosen because they are among the most frequent causes of renal injury in children. In addition, their nephrotoxicity is caused by different mechanisms.

What are nephrotoxic drugs for dogs?

And without further ado, here are the top 5 most dangerous kidney poisons to keep out of reach of your dog!

  • Non-steroidal anti-inflammatory drugs (NSAIDS)
  • Grapes, raisins, and currants.
  • Ethylene glycol (EG)
  • Vitamin D3.
  • Cardiac medications.

Which antibiotic is most nephrotoxic?

Two antibiotics associated with nephrotoxicity that are used to treat dangerous resistant infections are vancomycin and colistin.

Is doxycycline nephrotoxic?

Review of the literature suggests that occasional patients may have impairment of the nonrenal excretory pathway for doxycycline. We speculate that these patients are at risk for developing nephrotoxic levels of this antibiotic. 1.

Can NSAIDs cause kidney failure in dogs?

Non-steroidal anti-inflammatory drugs (NSAID’s) can cause renal damage, especially if over dosed. This most frequently happens when a dog, receiving a chewable form for arthritis, chews up and eats the whole bottle of pills! Be sure these bottles are out of reach of all your pets.

What poison can cause kidney failure?

Introduction. Paraquat, a rapidly-acting herbicide, is a leading cause of fatal poisoning when ingested [1]. Paraquat poisoning causes multi-organ failure over a period of hours to days, such as acute kidney injury (AKI), metabolic acidosis, and acute respiratory distress syndrome.

What antibiotic has the least nephrotoxic effect?

In general, appropriately dosed vancomycin in noncritically ill patients for the treatment of less serious infections has minimal risk of nephrotoxicity (13).

Which of the following antibiotic is least nephrotoxic?

Among these treatment groups, tobramycin was the least nephrotoxic of the aminoglycosides. Nephrotoxicity, as defined above, was lower for the β-lactam antibiotics than for the aminoglycoside groups combined; however, the decrease was not significant.

What antibiotic is safest for the kidneys?

Penicillins are generally well tolerated in patients with kidney disease. Hypersensitivity reactions are commonly reported, and an association between penicillins and interstitial nephritis exists, but patients with kidney disease are not considered to be at higher risk (10).

Does doxycycline raise creatinine levels?

Glomerular filtration rate, effective renal plasma flow, serum creatinine and blood urea did not change significantly during doxycycline administration, neither did any of the other parameters measured.